Fig. 3: Pan-cancer atlas of healthy tissue-resident and solid TiNK cells. | Nature Immunology

Fig. 3: Pan-cancer atlas of healthy tissue-resident and solid TiNK cells.

From: Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping

Fig. 3: Pan-cancer atlas of healthy tissue-resident and solid TiNK cells.

a, Graphic overview of healthy tissue datasets included in the analysis, with the number of donors denoted in brackets. b, UMAP representation showing integration of all healthy tissue datasets. c, Graphic overview of solid tumor datasets included in the analysis, with the number of donors denoted in brackets. d, UMAP representation showing integration of all solid tumor datasets. e, Scoring of tissue-residency signatures (sig.) in PB-NK cell subsets, as well as CD56bright- and CD56dim-annotated TrNK and TiNK subsets. f, UMAP representation showing integration of subset-annotated PB-NK, TrNK and TiNK cells. g,h, PAGA graphs (g) and connectivity heatmap (h) showing connectivity of PB-NK, TrNK and TiNK subsets across all tissues/tumor types, with individual tissues/tumor types highlighted (g). The scale represents gene set activity computed by AUCell (e). Panels a and c created with BioRender.com.

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