Extended Data Fig. 7: Intercellular communication between sender cells and Treg cells in UVM.
From: An atlas of genetic effects on cellular composition of the tumor microenvironment
a. CellChat predicted significant interactions (ligand-receptor pairs) from sender cell groups to regulatory T cells (Tregs), dot color reflects communication probability where dark and red colors correspond to the smallest and largest values, dot size represents computed P-value (left). Circle plot displays the signaling sent from one cell group to others in IL-1 signaling pathway, circle sizes are proportional to the number of cells in each cell group, and thicker edge line indicates a stronger signal. b. Intercellular communication assessed by NicheNet, showing the ranked ligand activity prediction, expression level of ligands in sender cells, interaction potential of ligands to the receptors in Treg cells and regulatory potential of ligands to the target genes in Treg cells.
