Extended Data Fig. 8: Study design to estimate CRC genetic risk in multi-ethnic populations.
From: An atlas of genetic effects on cellular composition of the tumor microenvironment
Three polygenic risk score (PRS) approaches for CRC risk stratification were constructed in East Asian (EAS) and European (EUR) populations. Next, the evaluation of three PRS models for assessing genetic susceptibility to CRC were performed in the case-control set from Chinese and European populations. Lastly, the predictive performance on CRC of these three PRS models were further assessed in the UK Biobank cohort.
