Extended Data Fig. 5: Distinct bone marrow profiles of caspase 1 and 11 deficient mice irrespective of Eμ-myc.

a,b, Heatmaps showing normalized expression levels of differentially expressed genes from selected enriched GO terms. Genes shown are differentially regulated by Casp1^−⁄− Casp11^−⁄− in both Eμ-myc and WT backgrounds. a, Genes in response to TGF-β, positive regulation of vasculature development, and cell-cell signaling by Wnt are shown. b, Genes in response to cellular respiration, mitochondrial respiratory chain complex assembly, mitochondrial organization, mitochondrial ATP synthesis coupled electron transport, and protein targeting to mitochondria are shown. Color scale indicates row z score of normalized read counts. c, Gene Ontology (GO) biological process terms most significantly enriched among genes differentially expressed due to Eμ-myc in both Casp1^−⁄− Casp11^−⁄− and wild type backgrounds. Common genes indicated in purple in Venn diagrams in Fig. 3c). Enrichment p values were corrected using the method of Benjamini and Hochberg.