Extended Data Fig. 8: Expression of ISG Modules Across COVID-19 Severity.
From: Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
a-b) Violin plots of IFN alpha (a) and IFN gamma (b) response gene module scores in ciliated (n = 15,180 cells), secretory (n = 6,656), and T cells (n = 2,181) from all ancestral (n = 32), Delta (n = 33), and Omicron (n = 21) cases. Cells are separated by COVID-19 severity score (WHO range 0–8). Genes uses for module score were derived from previously published results of stimulating human nasal basal cells with IFN alpha or IFN gamma (Supplementary Table 10)70. Lines represent local regression using locally estimated scatterplot smoothing. Error bands represent normal confidence interval.
