Extended Data Fig. 3: Inflammatory response is not detected in healthy human kidney tissue. | Nature Immunology

Extended Data Fig. 3: Inflammatory response is not detected in healthy human kidney tissue.

From: The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells

Extended Data Fig. 3: Inflammatory response is not detected in healthy human kidney tissue.The alternative text for this image may have been generated using AI.

a, Representative images showing PAS-stained human healthy kidney sections. Scale bars indicate 100 mm (left) and 40 mm (right). The experiment was repeated 5 times. b, Graphs showing the frequency of IL-17A+, IFN-γ+ and GM-CSF+ CD4+ T cells isolated from the matched blood and healthy kidney. T cells were treated with Brefeldin A in the presence or absence of PMA+Iono for 6 hours (n = 5). c,d, Heatmap showing the expression of cytokine-responsive genes in the kidney (c) and graphs showing the quantification of the cytokine-responsive genes as a score (Healthy: n = 21; ANCA: n = 22; Lupus: n = 32; IgA: n = 27) (d). Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test; * p < 0.05, ** p < 0.01.

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