Extended Data Fig. 7: IL-10 downregulates an IRF1-mediated rheostat to suppress TLR4-induced expression of inflammatory NF-κB target genes and ISGs. | Nature Immunology

Extended Data Fig. 7: IL-10 downregulates an IRF1-mediated rheostat to suppress TLR4-induced expression of inflammatory NF-κB target genes and ISGs.

From: IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms

Extended Data Fig. 7

TLR4 signaling induces expression of IRF1, which amplifies induction of inflammatory NF-κB target genes, IFNB, and ISGs in partnership with IRF5 and ISGF3. IFN-β further augments expression of IRF1 (lower right), which in turn will increase IFN-β production; this identifies an amplification loop for increasing expression of ISGs and inflammatory genes. IRF1 also auto-amplifies its own expression. IL-10 turns down this IRF1-mediated rheostat, interrupts the IFN-β-IRF1 amplification loop, and suppresses IRF transcription factor activity to broadly downregulate induction of inflammatory and interferon response genes. Created in BioRenders.com.

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