Extended Data Fig. 8: Pro-inflammatory genes are not broadly induced in bat organoids treated with IFN or infected with RNA viruses.
From: Bat organoids reveal antiviral responses at epithelial surfaces
a, Heatmap showing gene expression log2-fold changes (from EdgeR bulk RNA-seq differential gene expression analysis) of selected pro-inflammatory genes and selected ISGs in universal IFNα2 (uIFNα2) or IFNλ1 vs. mock-treated human SIORG or human BronchialALI (n = 3 each). b, Same as for (a) but for IFN-treated bat SIORG (n = 3), bat alvORG (n = 3), or bat nasalORG (n = 3). c, Same as for (a) but for MARV-, MERS-CoV- or SeV-infected bat alvORG (n = 3 each), SeV-infected bat SIORG (n = 3), or MARV-infected bat nasalALI (n = 3). Comparisons used for calculation of edgeR log2-fold change are indicated in the legend.
