Extended Data Fig. 5: Ctsl calibrates the positively selecting signal strength. | Nature Immunology

Extended Data Fig. 5: Ctsl calibrates the positively selecting signal strength.

From: Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells

Extended Data Fig. 5: Ctsl calibrates the positively selecting signal strength.The alternative text for this image may have been generated using AI.

a, Thymocyte subset cell numbers (Mean ± SEM) in Ctsl+/+Rag1−/−Lm54Tg (n = 3) and CtslΔTECRag1−/−Lm54Tg mice (n = 4). b, Thymocyte subset cell numbers (Mean ± SEM) in Ctsl+/+Rag1−/−Lm6Tg (n = 6) and CtslΔTECRag1−/−Lm6Tg mice (n = 7). c, CD6 surface expression (MFI ± SEM) at consecutive DP and CD4SP differentiation stages in Ctsl+/+Rag1−/−Lm54Tg (n = 4) and CtslΔTECRag1−/−Lm54Tg mice (n = 5), assessed by flow cytometry. P-value by Student’s two-tailed t-test.

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