Extended Data Fig. 2: pTau staining in P301S −/− mice and gating strategy to identify microglia subpopulations. | Nature Immunology

Extended Data Fig. 2: pTau staining in P301S −/− mice and gating strategy to identify microglia subpopulations.

From: Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia

Extended Data Fig. 2: pTau staining in P301S −/− mice and gating strategy to identify microglia subpopulations.The alternative text for this image may have been generated using AI.

a, Representative image shows pTau (AT8) staining (green) in the spinal cord of a P301S−/− control mouse (n = 6). Nuclei are blue. Location of magnified inset image is denoted by a white box. b, Representative FACS plots of leukocytes from the spinal cord of a P301S+/+ mouse show the gating strategy used to identify microglia in Fig. 1e,f. c, Histograms depict expression of CD45, CX3CR1, P2RY12, CD11b, F480, CD11c, and MHCII as well as FSC and SSC on homeostatic microglia (blue), CD11c+ microglia (green), CD11c+ MHCII+ microglia (pink) described in Figs. 1e,f and 7d,e.

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