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T cell memory

Six degrees of TGFβ

Nature Immunology volume 26, pages 1221–1222 (2025) Cite this article

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TGFβ-mediated signals enable CD8+ T cells to establish tissue-residence. IL-4 and PD-1 are each connected to TGFβ signaling to regulate the formation of CD8+ T cell tissue residence in skin.

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Fig. 1: IL-4Rα and PD-1 signals converge with TGFβ signaling to regulate CD8+ TRM cells formation.
The alternative text for this image may have been generated using AI.

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Authors and Affiliations

  1. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA

    Quinn Peters & Martin Prlic

  2. Department of Global Health, University of Washington, Seattle, WA, USA

    Quinn Peters & Martin Prlic

Authors
  1. Quinn Peters
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  2. Martin Prlic
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Correspondence to Martin Prlic.

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The authors declare no competing interests.

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Peters, Q., Prlic, M. Six degrees of TGFβ. Nat Immunol 26, 1221–1222 (2025). https://doi.org/10.1038/s41590-025-02201-y

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