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B cell differentiation

A unique p52 NF-κB–ETS1 interaction ushers in a new paradigm of germinal center responses

A complex of the NF-κB family member p52 and the transcription factor ETS1 is required for B cell germinal center responses to T cell-dependent immunization and for IgE-dependent allergic responses.

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Fig. 1: Transcriptional p52–ETS1 complexes that regulate GC fates.

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Correspondence to Lee Ann Garrett-Sinha.

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Garrett-Sinha, L.A., Sinha, S. A unique p52 NF-κB–ETS1 interaction ushers in a new paradigm of germinal center responses. Nat Immunol 26, 1434–1435 (2025). https://doi.org/10.1038/s41590-025-02246-z

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