Fig. 6: Human cross-tissue disease fibroblast populations.
a, Human tissues previously included in cross-tissue fibroblast studies and the fibroblast subtypes they have identified (above heatmap), colored by study (Buechler et al.4 in green, Korsunsky et al.6 in orange and Gao et al.5 in blue). Heatmap shows gene expression of marker genes previously reported for cross-tissue fibroblast populations in our lesional skin fibroblast subtypes. Immediately above the heatmap we show the skin fibroblast subtype with most similar gene expression to reported cross-tissue populations. b, UMAP visualization for cross-tissue integration (left) and for fibroblasts specifically (right), colored by tissue. Color bars indicate expression (log1P norm). c, UMAP visualization for fibroblasts colored by re-annotated clusters (Methods). d, Dotplots of expression of marker genes we previously used for skin fibroblasts in cross-tissue atlas clusters by tissue type. Note that not all genes were available as the endometrial dataset contained ~17,000 genes. Illustrations in a were partly created using BioRender.com.
