Fig. 7: Cross-tissue F3: FRC-like fibroblasts and F6: inflammatory myofibroblasts regulate skin immune niches.
a, Proportion of disease-associated F3: FRC-like fibroblasts, F6: inflammatory myofibroblasts and F7: myofibroblasts in non-skin tissues by disease (left) and disease category (right). b, Dotplot of F3: FRC-like expression across diseases (skin and non-skin) (left). Dotplot of F6: inflammatory myofibroblasts gene expression across diseases (skin and non-skin) (right). Diseases with a minimum of 50 cells. c, H&E slide of lesional atopic dermatitis skin with annotation of perivascular infiltrate regions (top left). Niche identification and proportion of cells in the perivascular superficial niche (bottom left). Composition of the perivascular superficial niche in 10x Genomics Xenium. Insert: zoomed in version of perivascular niche cluster. d, Cell–cell communication analysis for F6: inflammatory myofibroblasts and skin immune cells (Methods). TCM, T central memory. e, Proportion of F6: inflammatory myofibroblasts in IBD by intestinal tissue inflammation status and linear regression of proportion with inflammation scores with 95% CI. f, Schematic summary of cell–cell interactions for F3: FRC-like fibroblasts and F6: inflammatory myofibroblasts. Schematic in f were created using BioRender.com.
