Extended Data Fig. 6: Profiling of renal biopsies of patients reveals PC1-associated transcriptional and clinical heterogeneity. | Nature Immunology

Extended Data Fig. 6: Profiling of renal biopsies of patients reveals PC1-associated transcriptional and clinical heterogeneity.

From: Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease

Extended Data Fig. 6: Profiling of renal biopsies of patients reveals PC1-associated transcriptional and clinical heterogeneity.The alternative text for this image may have been generated using AI.

a, Distribution of PC1 values across regions of interest (ROIs) from an individual patient’s biopsy. ROIs are color-coded by cluster identity and ordered along the Y-axis by increasing PC1 values and clinical condition. b, Correlation between the median PC1 value of ROIs from each patient and clinical variables: estimated glomerular filtration rate (eGFR), albuminuria and age (Pearson´s correlation, two-sided). c, Correlation between the ANCA Renal Risk (ARR) score of patients diagnosed with ANCA-GN and the median PC1 values of ROIs of their biopsy sample (Spearman’s correlation, two-sided). d, Differential gene expression analysis between ROIs classified as cluster 1 compared to those classified under clusters 2, 3 or 4. e, Expression of genes higher in cluster 1 ROIs shown in representative patients. f, Expression of genes higher in cluster 2-4 ROIs shown in representative patients.

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