Extended Data Fig. 10: Comparison of cell type proportions and differential gene expression in ANCA-associated biopsies using single-nucleus RNA sequencing and Xenium spatial transcriptomics. | Nature Immunology

Extended Data Fig. 10: Comparison of cell type proportions and differential gene expression in ANCA-associated biopsies using single-nucleus RNA sequencing and Xenium spatial transcriptomics.

From: Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease

Extended Data Fig. 10: Comparison of cell type proportions and differential gene expression in ANCA-associated biopsies using single-nucleus RNA sequencing and Xenium spatial transcriptomics.The alternative text for this image may have been generated using AI.

a, Comparison of cell type proportions in biopsies from ANCA patients between NucSeq and Xenium datasets. b–d, Log fold change in expression of specific gene groups between ANCA and control samples, as measured by NucSeq and Xenium: MMP genes (b), ADAM genes (c), and fibrosis-related genes (d). The fibrosis related genes for human kidney were taken from Fibrotic Disease-associated RNAome database (http://www.medsysbio.org/FDRdb). * show p-value < 0.05, two-sided Wilcoxon test with Benjamini-Hochberg correction.

Back to article page