Extended Data Fig. 5: Foxp3 degradation in developed T_reg cells induces minimal gene expression and chromatin accessibility changes.

(a) UMAP visualization of scRNA-seq data from Foxp3^AIDR26^WT and Foxp3^AIDR26^TIR1(F74G) T_reg cells on days 0, 3 and 7 of 5-ph-IAA-induced Foxp3 degradation. (b) UMAP visualization of representative genes from the single-cell RNA-seq dataset colored by expression level. (c) MA plot showing differentially accessible ATAC-seq peaks induced by Foxp3 degradation (left) and Foxp3 gene deficiency (right). Red points represent differentially accessible regions.