Extended Data Fig. 10: Foxp3 degradation leads to tumor shrinkage with minimal adverse effects. | Nature Immunology

Extended Data Fig. 10: Foxp3 degradation leads to tumor shrinkage with minimal adverse effects.

From: Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells

Extended Data Fig. 10: Foxp3 degradation leads to tumor shrinkage with minimal adverse effects.The alternative text for this image may have been generated using AI.

(a–b) Representative flow cytometry plots (a) and combined data (b) of Ki67 expression and EdU incorporation in Treg cells from the tumor and tumor-draining lymph node (dLN). Scatter-plot shows mean ± SEM. Each point represents a unique mouse. Data are representative of two independent experiments. Two-tailed t-test. (c) Representative flow cytometry plots (left) and combined data (right) of IFN-γ production by tumor-infiltrating NK cells. Scatter-plot shows mean ± SEM. Each point represents a unique mouse. Data are pooled from two independent experiments. Two-tailed t-test. (d) Representative flow cytometry plots (left) and quantification (right) of IFN-γ production by tumor-infiltrating ZsGreen− CD4 T cells. Scatter-plot shows mean ± SEM. Each point represents a unique mouse. Data are pooled from two independent experiments. Two-tailed t-test. (e) Volcano plts showing the number of genes up- and downregulated in Foxp3AIDR26TIR1(F74G) tumor Treg cells within each clustered defined in Fig. 7(l).

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