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Brain fibroblasts

Fibroblasts take center stage in brain repair

A recent Nature paper presents findings that highlight brain fibroblasts as dynamic regulators of tissue repair and immunomodulation after injury, with implications for understanding scar formation, function and long-term outcomes of acute brain injuries.

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Fig. 1: In the healthy brain, fibroblasts exist as distinct subtypes within the dural, arachnoid and pial meningeal layers, as well as in the perivascular spaces surrounding arterioles and venules.

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Correspondence to Costantino Iadecola.

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Garcia-Bonilla, L., Anrather, J. & Iadecola, C. Fibroblasts take center stage in brain repair. Nat Immunol 26, 1842–1844 (2025). https://doi.org/10.1038/s41590-025-02310-8

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