Extended Data Fig. 6: scRNA-seq analyses of publicly available mouse and human intestinal stromal cell datasets. | Nature Immunology

Extended Data Fig. 6: scRNA-seq analyses of publicly available mouse and human intestinal stromal cell datasets.

From: TSLP links intestinal nutrient sensing with amplification of the ILC2–tuft cell circuit

Extended Data Fig. 6: scRNA-seq analyses of publicly available mouse and human intestinal stromal cell datasets.The alternative text for this image may have been generated using AI.

a, Heatmaps representing expression levels of gut hormone receptors in PDGFRahi telocytes15, PDGFRalo trophocytes15, CD31+LYVE1− endothelial cells15, LYVE1+ LECs15, Foxl1+ telocytes16 and Foxl1− stromal cells16 from mouse datasets. b-d, 10x Genomics published Visium mouse small intestine dataset59. b, Hematoxylin and eosin staining of the intestinal tissue specimen. c, Color-coded cell clusters in the lamina propria (LP) shown in situ (top) and on a UMAP (bottom). d, UMAP feature plots representing gene expression level and distribution of Pdgfra, Lyve1, Tslp and Glp2r. Tslp and Glp2r expression enriched in the stromal populations of intestinal LP. e-h, Analyses of human intestinal datasets24,25. e, UMAP representing cell clustering of human dataset24. f, Feature plots of TSLP (left) and GLP2R (right) expression levels. g, UMAP representing cell clustering of human dataset25. h, Feature plots of TSLP (left) and GLP2R (right) expression levels.

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