Extended Data Fig. 2: Growth phenotypes of primary tumors, and upon challenge in secondary naïve WT hosts. | Nature Immunology

Extended Data Fig. 2: Growth phenotypes of primary tumors, and upon challenge in secondary naïve WT hosts.

From: Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity

Extended Data Fig. 2: Growth phenotypes of primary tumors, and upon challenge in secondary naïve WT hosts.The alt text for this image may have been generated using AI.

a, Growth profile of individual tumors following s.c. inoculation with 3-methylcholanthrene (MCA) in WT (n = 12), RAG1KO (n = 12) and DNGR-1KO (n = 11) mice, during the surveillance period of 150 days. Data are plotted as tumor volume (mm3). Data are representative of four independent experiments; supporting data for Fig. 1a. b-d, Dot plots of the estimated time to establish tumors ≥250 mm3 for each primary tumor cell line, based on the respective fitted exponential (Malthusian) modeling for each individual growth profile, from (b) WT (n = 26), (c) RAG1KO (n = 19) and (d) DNGR-1KO (n = 24) hosts; supporting data for Fig. 2b–e, respectively. Data are presented as median and interquartile range. As indicated in red, progressors established tumors ≥250 mm3 within 25 days of challenge in naïve WT secondary hosts. Meanwhile, as indicated in blue, regressors are completely rejected or controlled (failed to establish tumors ≥250 mm3 within 25 days). For tumors which were completely rejected, time was assigned an arbitrary value of 300 days, indicating infinite time.

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