Previous Zika virus infection results in the production of anti-NS1 IgA antibodies that complex with soluble NS1 from subsequent dengue virus infection to activate neutrophils, which release pro-inflammatory mediators to exacerbate the risk of severe dengue.
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E.E.O. has served in advisory capacities on dengue to Sanofi Pasteur, Takeda Pharmaceuticals, MSD (Merck), Johnson and Johnson and Novartis.
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Ooi, E.E. Zika immune imprint risks dengue. Nat Immunol 27, 10–11 (2026). https://doi.org/10.1038/s41590-025-02365-7
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DOI: https://doi.org/10.1038/s41590-025-02365-7
