New data show that DNGR-1 enables type 1 conventional dendritic cells to sculpt cancer immunoediting through selective cross-presentation of F-actin-tethered neoantigens, enriching tumors for immune-evasive variants.
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Blander, J.M., Jha, A. Tethered neoantigens from the dead sculpt tumor fate. Nat Immunol 27, 7–9 (2026). https://doi.org/10.1038/s41590-025-02367-5
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DOI: https://doi.org/10.1038/s41590-025-02367-5
