Lymph node-like structures form at the brain border in some individuals with multiple sclerosis, creating compartmentalized inflammation linked to gray matter injury. We reveal how these discrete immune hubs develop, how they can be targeted for therapeutic purposes and how to identify patients who would benefit most from such therapies.
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References
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This is a summary of: Naouar, I. et al. Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury. Nat. Immunol. https://doi.org/10.1038/s41590-025-02359-5 (2026).
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A molecular circuit at the brain border that drives gray matter injury. Nat Immunol 27, 14–15 (2026). https://doi.org/10.1038/s41590-025-02378-2
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DOI: https://doi.org/10.1038/s41590-025-02378-2
