Extended Data Fig. 2: BACH2 overexpression alters CAR T cell phenotypes.
From: BACH2 regulates T cell lineage state to enhance CAR T cell function
a, Expression of BACH2 in bulk, CD4 and CD8 CAR T cells at the conclusion of manufacturing. b, Expression of TIM3 and LAG3 in CAR T cells at the end of manufacturing (n = 3 donors). c, Memory composition of bulk, CD4 and CD8 CAR T cells at the conclusion of manufacturing. d, Memory subtype composition of CD19 and CD33 CAR T cell products (representative of n = 2 donors). e, Expansion of CAR T cells over time in a chronic stimulation assay. All data are represented as either individual values or mean values ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by two-way ANOVA with Bonferroni adjustment for multiple comparisons.
