Comparative single-cell transcriptomic analysis identifies clonally expanded tissue-resident CD8+ T cells within the leptomeninges of individuals with neurodegenerative diseases. The findings suggest that this brain border region represents an active immune niche that contributes to neurodegeneration with disease-specific distinctions.
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Acknowledgements
Funding was provided by The Phil & Penny Knight Initiative for Brain Resilience at the Wu Tsai Neurosciences Institute, Stanford University (to H.E.E. and K.I.A.), BrightFocus Foundation Postdoctoral Award (to H.E.E.), and NIH/NIA 1P30 AG066515 (to K.I.A.).
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Ennerfelt, H.E., Andreasson, K.I. A new blueprint of brain border immunity. Nat Immunol (2026). https://doi.org/10.1038/s41590-025-02404-3
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DOI: https://doi.org/10.1038/s41590-025-02404-3
