Extended Data Fig. 2: Transient cell cycle arrest enhanced CD8+ T cell proliferation in vivo. | Nature Immunology

Extended Data Fig. 2: Transient cell cycle arrest enhanced CD8+ T cell proliferation in vivo.

From: Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling

Extended Data Fig. 2

a, Naïve mice were vaccinated with E7 SLP/CpG on day 0 and either left untreated or treated with topotecan (Topo) for three consecutive days (n=7). Left: Percentages (mean ± SEM) of circulating E749-57-specific CD8+ T cells over time. Middle: normalized values relative to the peak response. Right: Percentages (mean ± SEM) of KLRG1+CD44+ CD8+ T cells over time (n=7 per group). b, Percentage of total CD8+ T cells among live cells following E7 SLP/CpG vaccination in mice either untreated or treated with HU (4 consecutive days, n=6) or Topo (3 consecutive days, n=7). c, Naïve mice were vaccinated with E7 SLP/CpG on day 0 and either left untreated (n=6) or treated with HU for 4 consecutive days (n=5). (PD-1 expression (geometric MFI ± SEM) on E749-57-specific CD8+ T cells was measured over time. Statistical comparisons were performed using two-sided unpaired t-test (a, b); P values are shown on the graphs.

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