FOXP3+ regulatory T (Treg) cells are pivotal for peripheral tolerance and immune suppression. We show that the skin-derived cytokine TSLP promotes GATA3-expressing effector Treg cells through a specific migratory DC2 subtype derived from transitional dendritic cells whose function requires OX40L, identifying a previously unrecognized tolerogenic axis across contexts of inflammation and cancer.
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References
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This is a summary of: Guivarch, M. et al. TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs. Nat. Immunol. https://doi.org/10.1038/s41590-025-02400-7 (2026).
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A tolerogenic role for transitional dendritic cells in inflammation and cancer. Nat Immunol (2026). https://doi.org/10.1038/s41590-026-02417-6
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DOI: https://doi.org/10.1038/s41590-026-02417-6
