Extended Data Fig. 6: B cell lineage bias in YP BM originates at the level of LyP. | Nature Immunology

Extended Data Fig. 6: B cell lineage bias in YP BM originates at the level of LyP.

From: Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling

Extended Data Fig. 6: B cell lineage bias in YP BM originates at the level of LyP.

Heatmap showing the relative expression of the top 10 differentially expressed genes identified in CITE-seq data across B cell populations, HSPC and myeloid cell populations (as defined in Fig. 1b), comparing young pediatric (YP; age 2.1–9.6 years; n = 4 donors, 2 male and 2 female) and adolescent and young adult (AYA; age 13.3–16.7 years; n = 3 donors, 1 male and 2 female) samples. Abbreviations: YP, young pediatric; AYA, adolescent and young adult; HSPC, hematopoietic stem and progenitor cells; HSC, hematopoietic stem cell; LMPP, lymphoid–myeloid primed progenitor; MEP, megakaryocyte–erythroid progenitor; McP, mast cell progenitor; LyP, lymphoid progenitor.YP, young pediatric; AYA, adolescents and young adults; HSPC, hematopoeitic stem and progenitor cells; HSC, hematopoietic stem cell; LMPP, lympho-myeloid primed progenitor; MEP, megakaryocyte-erythroid progenitor; McP, mast cell progenitor; LyP, lymphoid progenitor.

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