Supplementary Figure 7: EGFR SOMAmer versus antibody quantitative labeling comparison.
From: Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging
(a) qPAINT analysis of single EGFR proteins labeled with SOMAmer reagents (n = 2670) yields a unimodal distribution of binding events, confirming quantitative 1:1 labeling of EGFR proteins. (b) qPAINT analysis of single EGFR proteins (n = 3406) labeled with antibody reagents yields a multimodal distribution of binding events, confirming non-quantitative labeling of EGFR proteins.
