Supplementary Figure 1: The distribution of chromosome-specific repeats in the human genome.
From: CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging
(a) The distribution of chromosome-specific repeats in the human genome is shown. Green represents loci having ≥100 copies of target sites by CRISPR imaging on a repetitive DNA region, red these having 20–99 copies and blue those having 5–19 copies. The copy numbers were defined as the numbers of highest non-overlapping target sites in each repetitive region. (b) Histogram showing the frequency distribution of the chromosome-specific unique repeats as a function of the copy number of the internal core sequence in each: blue: 5–19 copies; red: 20–99 copies; green*: sum of all repeats ≥100 copies.
