Supplementary Figure 7: FIT rescues human DEGs undetected by the mouse with increased performance by relying on confidence intervals.
From: Found In Translation: a machine learning model for mouse-to-human inference
(a) The number of putative genes (genes predicted by FIT to be human-relevant, but not by the mouse) is shown for each disease in the FIT-improved disease set. About one-third of the putative genes are validated by the human data (i.e. rescued). The percent of rescued genes out of the putative genes per disease is shown next to each bar. (b) Confidence intervals (CI) can be used as reliability scores for FIT predictions. Putative genes having the 30% smallest CIs are validated as human DEGS at a higher fraction compared to all putative genes, across all FIT-improved diseases.
