Supplementary Figure 4: Mutation patterns at m1A sites in sequence contexts.
From: Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA
Heatmaps show mutation patterns (A to T, G, or C) of the wild-type and evolved RT variants in 256 sequence contexts in the ModSig-m1A library, in comparison to those in the control ModSig-A library. Yellow boxes are sequence contexts not covered by the sequencing data.
