Supplementary Figure 15: Network showing high-confidence interactions forming putative signaling paths between the ligand TGFB3 and its predicted target genes TGFBI, LAMC2 and TNC.

From NicheNet’s weighted integrated signaling and gene regulatory networks, we inferred the most important signaling mediators and transcriptional regulators involved in the signaling from TGFB3 to TGFBI, LAMC2, and TNC. Shown here is the network of interactions (as documented by NicheNet’s data sources) between ligand, signaling mediators, transcriptional regulators, and target genes. The ligand node is indicated in red, the target gene nodes in blue and nodes of signaling and transcriptional regulators in grey. Edge line thickness is proportional to the weight of the represented interaction in the weighted integrated networks. Edges representing signaling interactions are colored red, gene regulatory interactions blue.