Supplementary Figure 7: CRC Organoid Signaling Networks in the CRC TME Model. | Nature Methods

Supplementary Figure 7: CRC Organoid Signaling Networks in the CRC TME Model.

From: Cell-type-specific signaling networks in heterocellular organoids

Supplementary Figure 7

Signaling networks of 28 PTMs in colonic organoid cells from each genotype (wild-type (WT), shApc (A), shApc and KrasG12D/+ (AK), or shApc, KrasG12D/+, and Trp53R172H/- (AKP)) and microenvironment condition in the CRC TME model analyzed by MC. Signaling nodes are connected by DREMI edges and PTM activity is displayed as EMD relative to all cells across all conditions.

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