Supplementary Figure 8: Macrophage and Fibroblast Signaling Profiles in the CRC TME Model.
From: Cell-type-specific signaling networks in heterocellular organoids
a) and b) Signaling networks of 28 PTMs in macrophages and colonic fibroblasts from each genotype and microenvironment condition in the CRC TME model analyzed by MC. Signaling nodes are connected by DREMI edges and PTM activity is displayed as EMD relative to all cells across all conditions. c) and d) PCA of 28 PTM-EMDs for macrophages and colonic fibroblasts across all genotype/microenvironment combinations (10 conditions each). e) and f) PCA of 756 PTM-DREMIs for macrophages and colonic fibroblasts across all genotype/microenvironment combinations (10 conditions each).
