Extended Data Fig. 4: Analysis of RNA-seq data for L1CAM.
From: L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
(a) L1CAM intro-exon gene structure including Exon 25, which contains the only transmembrane domain. Alternative splicing skipping Exon 25 (L1CAM isoform without a transmembrane domain) would lead to transcripts with an exon-exon junction across Exon 24 and Exon 26. (b) Reads from GTEx RNA-Seq data of human Tibial Artery loaded in Integrative Genome Browser (IGV) aligning to Exon 25 of L1CAM, which contain the transmembrane domain (highlighted in red). Aligned junction reads supporting the skipping of Exon 25 are indicated with black arrows.
