Extended Data Fig. 9: Compartment-specific splicing.

The compartment-specific regulated alternative splicing of (a) ATP5FC1, (b) MYL6, and, (c) PPP1R12A. For ATP5F1C, endothelial and stromal cells have a higher fraction of junctional reads for the exon exclusion event compared to other compartments. For MYL6, immune cells have lower fraction of junctional reads for the exon inclusion event compared to other compartments. For PPP1R12A, immune cells have a higher fraction of junctional reads for the exon inclusion event. The plots include the cell types in which the splice site has at least 20 junctional reads in at least 10 cells in at least one of the 4 datasets (two individuals and two technologies: 10X and SS2) were chosen. Dots represent the fraction of junctional reads for each alternative splice site in the celltype. For each dot, the outer ring (in white) shows the upper CI and the inner ring (color-coded) shows the lower CI. Box plots show the average alternative splice site for each cell across all technologies and individuals. Each box shows 25-75% quantiles of average splice site per cell. Arcs represent the average fractions at the compartment level. There is no dot when the alternative splice site has 0 junctional reads.