Extended Data Fig. 5: Splicing residual matrices.
From: The SpliZ generalizes ‘percent spliced in’ to reveal regulated splicing at single-cell resolution
SVD decompositions of the splicing residual matrix based on the simulations in Fig. 1d,f, and Extended Data Fig. 3 at average read depth 20. Rows correspond to splice sites and columns correspond to eigenvectors. For each splice site, the value from the SVD that causes the splice site to be picked as SpliZsite is boxed in green. a,b,c. As expected, all non-constitutive splice sites are selected as SpliZsites. d. As expected, the three most variable splice sites are chosen as SpliZsites, while the 99% constitutive splice site is not chosen as SpliZsite.
