Extended Data Fig. 9: Single-tissue eQTL analysis for the rs62088464-TSEN54 variant-gene pair from GTEx portal. | Nature Methods

Extended Data Fig. 9: Single-tissue eQTL analysis for the rs62088464-TSEN54 variant-gene pair from GTEx portal.

From: NEAT-seq: simultaneous profiling of intra-nuclear proteins, chromatin accessibility and gene expression in single cells

Extended Data Fig. 9

a) Normalized effect size (NES) across various tissues for the protective (G) vs risk (A) allele on TSEN54 expression. The risk allele preserves the GATA3 motif. A negative NES value indicates a gene with expression that is associated with the risk allele. Error bars indicate 95% confidence intervals. b) Normalized TSEN54 expression grouped by rs62088464 genotype for lung and esophagus mucosa. c) Genes ordered by NES across tissues for rs62088464. P-values for (b) and (c) are outputs from the GTEx portal (release v8) and are calculated from a two-sided t-test comparing the observed NES in a tissue to a null NES of 0.

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