Extended Data Fig. 5: Reproducibility across IGM replicates.

Reproducibility of 15 structural features in independent HDSF replicate calculations starting from different random starting configurations, see Methods. These features also include the reproducibility of cell-to-cell variability of several features from two independent population replicates. The high Pearson’s correlation values in each panel validate the robust reproducibility of all features (ICP = interchromosomal contact probability, SAF = speckle association frequency, LAF = lamina association frequency).