Fig. 2: Overview on open-microscopy hardware projects.

a, OpenFlexure devices enable 3D printed microscopes with high mechanical stability controllable via a web browser22. b, UC2 (‘you see, too’) is a general-purpose modular framework for interactive (electro)-optical projects23. c, The Squid platform represents a full suite of hardware and software components for rapidly configuring high-performance microscopes8. d, The smfBox enables diffusion-based measurements of individual biomolecules36. e, The MesoSPIM project presents open-hardware microscopy platforms for imaging cleared tissue28. f, The openFrame is a commercially available open-microscopy framework67. LA, LED array; xyz, xyz stage; MO, microscope objective; M, mirror; Cam, camera. Panel a adapted from ref. 22 under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/); panel b reproduced from ref. 23 under a Creative Common license (https://creativecommons.org/licenses/by/4.0/); panel c reproduced from ref. 8 under a Creative Commons license (https://creativecommons.org/licenses/by-nc-nd/4.0/); panel d reproduced from ref. 36 under a Creative Commons license (https://creativecommons.org/licenses/by-nc-nd/4.0/); panel e adapted with permission from ref. 28, Springer Nature; and panel f reproduced with permission from Jeremy Graham, ©2022, Cairn Research.