Extended Data Fig. 2: Single-trial and PSTH recovery in diverse brain areas.
Results are shown for M1 (a, b), area 2 (c, d) and DMFC (e, f). (a) Average reach trajectories (top), PSTHs (second row) and single-trial firing rates (bottom) obtained by smoothing (Gaussian kernel, 30 ms s.d.) or AutoLFADS for a single neuron across 4 reach conditions. Data is modeled at 2 ms bins. Dashed lines indicate movement onset and vertical scale bars denote rates (spikes per second). (b) Performance in replicating the empirical PSTHs computed on all trials using rates inferred from a 184-trial training set using AutoLFADS and LFADS with random HPs (100 models; no CD). (c) PSTHs and single-trial firing rates for a single neuron across 4 passive perturbation directions. Smoothing was performed using a Gaussian kernel with 10 ms s.d. Dashed lines indicate movement onset. (d) Comparison of AutoLFADS vs. random search (no CD) in matching empirical PSTHs. (e) PSTHs and single-trial firing rates for an example neuron during the ’set-go' period of leftward saccade trials across 4 different values of ts (vertical scale bar: spikes per second). Smoothing was performed using a Gaussian kernel with 25 ms s.d. (f) Performance in replicating the empirical PSTHs.
