Extended Data Fig. 5: Breeding for SELECTIV-Pax7CE mice with inducible muscle stem cell specific AAVR overexpression. | Nature Methods

Extended Data Fig. 5: Breeding for SELECTIV-Pax7CE mice with inducible muscle stem cell specific AAVR overexpression.

From: Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression

Extended Data Fig. 5: Breeding for SELECTIV-Pax7CE mice with inducible muscle stem cell specific AAVR overexpression.

Female SELECTIV-KO (LSL-Aavr-mCh+/−, Aavr−/−) mice were bred with male Pax7CE (Pax7-CreERT2) mice that were purchased from Jax (Stock No: 017763) to generate SELECTIV-Pax7CE (LSL-Aavr-mCh+/−, Pax7-CreERT2+/−, Aavr+/−). Treatment with tamoxifen by IP injection results in Pax7-dependent expression of the SELECTIV construct.

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