Extended Data Fig. 7: Permutation score analysis of old mouse brain.
From: Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells
a. Density of permutation score per cell type: arachnoid barrier cells (ABC), astrocyte-restricted precursors (ARP), astrocytes (ASC), choroid plexus epithelial cells (CPC), dendritic cells (DC), endothelial cells (EC), ependymocytes (EPC), hemoglobin-expressing vascular cells (Hb-VC), macrophages (MAC), microglia (MG), monocytes (MNC), neural stem cells (NSC), neuroendocrine cells (NendC), olfactory ensheathing glia (OEG), oligodendrocytes (OLG), oligodendrocyte precursor cells (OPC), pericytes (PC), vascular and leptomeningeal cells (VLMC), vascular smooth muscle cells (VSMC), mature neurons (mNEUR) (N=2000 genes each). b. Percentage of cell types scoring assigned the highest permutation socre for a given gene. c. Genes assigned the highest permutation score. d, UMAP embedding of dataset colored by whether cells are mature neurons (mNEUR). e, Permutation score densities (left), and their kurtosis and skew when using the full dataset (brown) compared to excluding mature neurons.
