Extended Data Fig. 4: Effect of data perturbation on uncertainty.
From: Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells
a. The effect of downsampling (0%, 25%, 50%, 75%) counts on phase portraits of Sulf2 (left) colored by cell type, intrinsic uncertainty per cell (middle, N=3696 cells), and extrinsic uncertainty per cell (right, N=3696 cells). b. The effect of unobserved unspliced reads (dropout probability 0.0, 0.5, 0.9, 0.98) in 400 and 800 genes on phase portraits of Fam135a (left), intrinsic uncertainty per cell (middle, N=3696 cells), and extrinsic uncertainty per cell (right, N=3696 cells). c. The effect of multiplicative noise (scale 0.1, 0.5, 1.0, 1.5) on phase portraits of Sulf2 (left), intrinsic uncertainty per cell (middle, N=3696 cells), and extrinsic uncertainty per cell (right, N=3696 cells). Box plots indicate the median (center line), and interquartile range (hinges).
