Extended Data Fig. 2: SUPPORT denoises volumetric structural imaging data.
From: Statistically unbiased prediction enables accurate denoising of voltage imaging data
a, Representative axial slice from low-SNR, SUPPORT-denoised, high-SNR volumes of Penicillium. b, Magnified views of the yellow boxed region in a at multiple axial locations. Axial location of a corresponds to 3.37 μm. c, Box-and-whisker plot showing Pearson correlation coefficient and signal-to-noise ratio for axial slices. A two-sided paired-sample t-test is used, N = 381, which represents the number of planes along the z-axis (***: p-value < 0.001). d, Intensity profiles of the cyan dashed line in a. e, Example frame of bone of a mouse embryo after expansion for the raw data (top) and denoised image using SUPPORT (bottom). f, Raw (top) and denoised image (bottom) of intestine of a mouse embryo. e-f, Length scales are presented in pre-expansion dimensions.
