Fig. 2: The catalytic rules most commonly observed in the M-CSA database.
From: EzMechanism: an automated tool to propose catalytic mechanisms of enzyme reactions
a–d, Rules match chemical groups, not amino acids or other molecules but, to facilitate comprehension, some molecules and amino acids that match these chemical groups are indicated in parentheses. a, Proton transfers with water species. b, Proton transfers between amino acids. c, Rules involving cofactors. d, Other common rules. Glu, glutamate; Asp, aspartate; His, histidine; Lys, lysine; Tyr, tyrosine; Cys, cysteine; PLP, pyridoxal 5′-phosphate; TPP, thiamine(1+) diphosphate; CoA, acetyl-coenzyme A; NAD, nicotinamide adenine dinucleotide and FAD, flavin adenine dinucleotide.
