Extended Data Fig. 1: Robustness assessment of CytoCommunity performance using different values of K in K-nearest-neighbor graphs.
From: Unsupervised and supervised discovery of tissue cellular neighborhoods from cell phenotypes
(a) Assessment using the mouse hypothalamic preoptic region MERFISH dataset. (b) Assessment using the human triple-negative breast cancer (TNBC) MIBI-TOF dataset. Robustness score is defined as the average Jaccard index between original TCN partitions and new TCN partitions generated using different K values. SRM, square root of the average number of cells (SRM) across images in the dataset. K values were varied around the SRM values. Each black point represents the robustness performance on a given single-cell spatial image (n = 5 for the MERFISH dataset and n = 34 for the MIBI-TOF dataset). Blue horizontal bars represent the means of each group.
