Extended Data Fig. 8: RNA structural heterogeneity impacts gene regulation.
From: RNA structure profiling at single-cell resolution reveals new determinants of cell identity
a, b, Boxplots showing the distribution of change in translation efficiency between YBX3 (a) or GRWD1 (b) target transcripts in hESC and NPCs when we separate YBX3 (a) or GRWD1 (b) target windows according to whether they are less or more accessible (left), homo or heterogeneous (middle), or both (right) in hESC. c, Boxplots showing the distribution of change in half-life between APOBEC3C target transcripts in hESC and NPCs when we separate APOBEC3C target windows according to whether they are less or more accessible (left), homo or heterogeneous (middle), or both (right) in hESC. The boxplots show the means and 25th to 75th percentile inter-quartile range, the bars show the range from 5th to 95th percentile. The numbers of genes in each boxplot are as shown. All the p-values were calculated by the two-sided Mann-Whitney U test in this figure.
